A Study to Test the Safety of Three Experimental HIV Vaccines

Completed · Phase 1

Conditions studied: HIV Infections, HIV Seronegativity

In brief

The purpose of this study is to test three experimental HIV vaccines. This study will look at whether it is safe to give these vaccines together and how the immune system responds to the vaccines. There are a number of studies being performed to test HIV vaccines. The vaccines that seem to be the most promising are canarypox vaccines, known as ALVAC vaccines. The three experimental HIV vaccines used in this study are called ALVAC-HIV vCP205, HIV-1 SF-2 p24, and HIV-1 SF-2 rgp120. The HIV-1 SF-2 p24 and HIV-1 SF-2 rgp120 vaccines are mixed with an adjuvant, which is a substance that increases immune response.

Key facts

Study ID

NCT00000946

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

40

Expected to finish

2001-03-01

Last updated by the study team

2021-10-29

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• You may be eligible for this study if you:
• Are between the ages of 18 and 60.
• Are HIV-negative.
• Are negative for Hepatitis B.
• Have a normal physical exam.
• Are available for 18 months of follow-up.
• Agree to use an effective method of birth control for 1 month before receiving a vaccine and during the study.

You may not qualify if…

• You will not be eligible for this study if you:
• Have a history of an immunodeficiency, chronic illness, or cancer.
• Have a medical or psychiatric condition which would make you unable to comply with the study.
• Are at higher-risk for HIV infection; for example, have a history of injection drug use in the past year or practice higher risk sexual behavior.
• Have syphilis or tuberculosis.
• Have received a live vaccine in the past 60 days, have ever received an HIV vaccine or placebo in a previous HIV vaccine study, or have ever received a rabies vaccine.
• Have a history of a serious allergic reaction to a vaccine or to any other substance, including neomycin or egg products.
• Have received certain medications.
• Are pregnant or breast-feeding.

Where it is running

• UAB AVEG — Birmingham, Alabama, United States
• JHU AVEG — Baltimore, Maryland, United States
• St. Louis Univ. School of Medicine AVEG — St Louis, Missouri, United States
• Univ. of Rochester AVEG — Rochester, New York, United States
• Vanderbilt Univ. Hosp. AVEG — Nashville, Tennessee, United States
• FHCRC/UW Vaccine CRS — Seattle, Washington, United States
• UW - Seattle AVEG — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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