A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

Completed · Not applicable

Conditions studied: HIV Infections, Leukoencephalopathy, Progressive Multifocal

In brief

The purpose of this study is to evaluate the safety, tolerance, and overall effectiveness of cidovir to treat PML in AIDS patients. PML is an opportunistic infection (HIV-associated, due to weak immune system) caused by a virus that attacks the brain. Cidovir has been used effectively to treat cytomegalovirus (CMV) of the eye. Cidovir could be an effective treatment for PML as well.

Key facts

Study ID

NCT00000945

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

24

Expected to finish

2001-03-01

Last updated by the study team

2021-10-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• You may be eligible for this study if you:
• Are HIV-positive.
• Have had symptoms of PML for no more than 90 days before study entry, or have had abnormal neurological exams related to PML.
• Have negative tests for bacterial or fungal infections.
• Agree to practice abstinence or use effective methods of birth control during the study.
• Are at least 18 years old.
• Have a life expectancy of at least 6 months.

You may not qualify if…

• You will not be eligible for this study if you:
• Have a history of uveitis.
• Are allergic to sulfa drugs or probenecid.
• Have had active opportunistic infections other than Kaposi's sarcoma within 30 days before study entry.
• Have sickle cell anemia or trait.
• Are pregnant or breast-feeding.

Where it is running

• Univ of Alabama at Birmingham — Birmingham, Alabama, United States
• San Francisco AIDS Clinic / San Francisco Gen Hosp — San Francisco, California, United States
• San Francisco Gen Hosp — San Francisco, California, United States
• Univ of Colorado Health Sciences Ctr — Denver, Colorado, United States
• Howard Univ — Washington D.C., District of Columbia, United States
• Northwestern Univ Med School — Chicago, Illinois, United States
• Cook County Hosp — Chicago, Illinois, United States
• Rush Presbyterian - Saint Luke's Med Ctr — Chicago, Illinois, United States
• Louis A Weiss Memorial Hosp — Chicago, Illinois, United States
• Johns Hopkins Hosp — Baltimore, Maryland, United States
• SUNY / Erie County Med Ctr at Buffalo — Buffalo, New York, United States
• Beth Israel Med Ctr — New York, New York, United States
• Bellevue Hosp / New York Univ Med Ctr — New York, New York, United States
• Mount Sinai Med Ctr — New York, New York, United States
• Univ of Rochester Medical Center — Rochester, New York, United States
• Univ of North Carolina — Chapel Hill, North Carolina, United States
• Univ of Kentucky Lexington — Cincinnati, Ohio, United States
• Julio Arroyo — West Columbia, South Carolina, United States
• Univ of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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