A Study on the Effect of Chemotherapy Combined With Anti-HIV Drugs in HIV-Positive Patients
Completed · Phase 1
Conditions studied: HIV Infections
In brief
The purpose of this study is to determine the safety of anti-HIV drugs combined with low-dose chemotherapy (consisting of cyclophosphamide \[CTX\]) in HIV-positive patients. This study examines whether this combination therapy can reduce the number of HIV-infected cells hidden in the lymph nodes and blood. Current anti-HIV drug treatments can greatly reduce the levels of HIV in the human body. However, HIV can hide in certain immune cells and escape the drugs' effects. Chemotherapy using CTX destroys these immune cells. When used with standard anti-HIV drug treatments, CTX may be able to speed up the elimination of HIV-infected cells.
Key facts
- Study ID
- NCT00000899
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 10
- Expected to finish
- 2001-10-01
- Last updated by the study team
- 2021-10-29
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- You may be eligible for this study if you:
- Are HIV-positive.
- Have a CD4 count above 300 cells/mm3 within 30 days of study entry.
- Have an HIV viral load between 10,000 and 200,000 copies/ml.
- Are between the ages of 18 and 50.
- Agree to practice abstinence or to use a barrier method of birth control during the study (such as condoms).
You may not qualify if…
- You may not be eligible for this study if you:
- Have had cancer requiring chemotherapy or radiotherapy or certain nervous system diseases.
- Are sensitive to E. coli-derived proteins.
- Have an active AIDS-defining illness.
- Require certain medications.
- Are pregnant or breast-feeding.
Where it is running
- Univ of North Carolina — Chapel Hill, North Carolina, United States
- Duke Univ Med Ctr — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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