Comparison of Two Drugs, Cidofovir and Ganciclovir, in Treating Patients With AIDS Who Have CMV Retinitis

Completed · Phase 4

Conditions studied: Cytomegalovirus Retinitis, HIV Infections

In brief

To compare cidofovir with a commonly used treatment regimen, ganciclovir given by mouth (oral) and through an eye device (intraocular) , in order to determine the safety and effectiveness of cidofovir in preventing vision loss in patients who have AIDS complicated by CMV (cytomegalovirus) retinitis. Cidofovir needs to be compared to ganciclovir to determine the best way to treat CMV retinitis.

Key facts

Study ID

NCT00000894

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

300

Last updated by the study team

2011-02-23

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• You may be eligible for this study if you:
• Are 13 years of age or older (parent or guardian consent required if under 18).
• Agree to practice sexual abstinence or use effective birth control during and for 90 days after the study.
• Have AIDS.
• Have CMV retinitis.

You may not qualify if…

• You will not be eligible for this study if you:
• Have a history of heart or kidney disease.
• Have medical problems which would prevent you from completing the study.
• Are pregnant.

Where it is running

• Univ of Southern California / LA County USC Med Ctr — Los Angeles, California, United States
• UCLA CARE Ctr — Los Angeles, California, United States
• Univ of Miami / Bascom Palmer Eye Institute — Miami, Florida, United States
• Emory Eye Clinic — Atlanta, Georgia, United States
• Northwestern Univ / SOCA — Chicago, Illinois, United States
• Charity Hosp / Tulane Univ Med School — New Orleans, Louisiana, United States
• Johns Hopkins Hosp — Baltimore, Maryland, United States
• Cornell Univ Med Ctr — New York, New York, United States
• New York Hosp / Cornell Med Ctr — New York, New York, United States
• Univ of North Carolina — Chapel Hill, North Carolina, United States
• Julio Arroyo — West Columbia, South Carolina, United States
• Univ of Texas Galveston — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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