A Study of Nevirapine for the Prevention of HIV Transmission From Mothers to Their Babies

Completed · Phase 3

Conditions studied: HIV Infections, Pregnancy

In brief

The purpose of this study is to see if giving the anti-HIV drug nevirapine (NVP) to HIV-positive pregnant women and their babies can help reduce the chance that a mother will give HIV to her baby during delivery. This study will also test the safety of the drug and see how well it is tolerated by the mother and her baby. Previous studies suggest that NVP is a promising medication for blocking HIV transmission from HIV-positive mothers to their babies.

Key facts

Study ID

NCT00000869

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

2009

Expected to finish

2001-05-01

Last updated by the study team

2021-10-28

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Women may be eligible for this study if they:
• Are HIV-positive.
• Are at least 20 weeks pregnant. (This study has been changed. Women no longer have to be 28 weeks pregnant.)
• Have consent from the child's father (if available).
• Are at least 13 years old (consent of parent or guardian required if under 18).

You may not qualify if…

• Women will not be eligible for this study if they:
• Have ever taken NNRTIs (nonnucleoside reverse transcriptase inhibitors).
• Are enrolled in another pregnancy treatment study.
• Are allergic to benzodiazepines.
• Have liver disease.
• Plan to breast-feed.

Where it is running

• Univ of South Alabama — Mobile, Alabama, United States
• UCSD Med Ctr / Pediatrics / Clinical Sciences — La Jolla, California, United States
• Long Beach Memorial (Pediatric) — Long Beach, California, United States
• Los Angeles County - USC Med Ctr — Los Angeles, California, United States
• UCLA Med Ctr / Pediatric — Los Angeles, California, United States
• Harbor - UCLA Med Ctr / UCLA School of Medicine — Los Angeles, California, United States
• San Francisco Gen Hosp — San Francisco, California, United States
• UCSF / Moffitt Hosp - Pediatric — San Francisco, California, United States
• Children's Hosp of Denver — Denver, Colorado, United States
• Connecticut Children's Med Ctr — Farmington, Connecticut, United States
• Univ of Connecticut / Farmington — Farmington, Connecticut, United States
• Washington Hosp Ctr — Washington D.C., District of Columbia, United States
• Howard Univ Hosp — Washington D.C., District of Columbia, United States
• North Broward Hosp District — Fort Lauderdale, Florida, United States
• Univ of Florida Gainesville — Gainesville, Florida, United States
• Univ of Florida Health Science Ctr / Pediatrics — Jacksonville, Florida, United States
• Univ of Miami / Jackson Memorial Hosp — Miami, Florida, United States
• Univ of Miami (Pediatric) — Miami, Florida, United States
• Med College of Georgia — Augusta, Georgia, United States
• The Med Ctr Inc — Columbus, Georgia, United States
• Cook County Hosp — Chicago, Illinois, United States
• Univ of Illinois College of Medicine / Pediatrics — Chicago, Illinois, United States
• Chicago Children's Memorial Hosp — Chicago, Illinois, United States
• Univ of Chicago Children's Hosp — Chicago, Illinois, United States
• Univ of Alabama at Birmingham - Pediatric — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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