A Study to Evaluate the Use of Memantine In Combination With Anti-HIV Drugs to Treat AIDS Dementia Complex (ADC)

Completed · Phase 2

Conditions studied: AIDS Dementia Complex, HIV Infections

In brief

The purpose of this study is to determine the safety and effectiveness of memantine, an experimental drug, in improving AIDS dementia complex (ADC). The symptoms of ADC can be improved with zidovudine (ZDV). However, ZDV therapy has been associated with significant toxicities, and the effectiveness of ZDV seems to decrease during the second and third years of therapy. The effectiveness of other antiretroviral drugs as treatment for ADC is not known, so it is important to explore alternative therapies.

Key facts

Study ID

NCT00000867

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

120

Starts

1996-12-01

Expected to finish

2001-07-01

Last updated by the study team

2013-06-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• You may be eligible for this study if you:
• Are HIV positive.
• Have been diagnosed with AIDS dementia complex (ADC).
• Have an estimated IQ of at least 70 (before the onset of ADC) or the ability to read at a 6th grade level.
• Have impaired mental skills.
• Are age18 or older.

You may not qualify if…

• You will not be eligible for this study if you:
• Have a history of a neurologic disease unrelated to HIV infection.
• Have a history of chronic seizures or head injuries.
• Have a history of central nervous system infections.
• Have certain cancers.
• Have any psychiatric illness.
• Have an active AIDS-defining opportunistic infection.
• Are pregnant or breast-feeding.

Where it is running

• UCLA CARE Center CRS — Los Angeles, California, United States
• Ucsf Aids Crs — San Francisco, California, United States
• Univ. of Miami AIDS CRS — Miami, Florida, United States
• Queens Med. Ctr. — Honolulu, Hawaii, United States
• Univ. of Hawaii at Manoa, Leahi Hosp. — Honolulu, Hawaii, United States
• Northwestern University CRS — Chicago, Illinois, United States
• Cook County Hosp. CORE Ctr. — Chicago, Illinois, United States
• The Univ. of Kentucky, Lexington A2405 CRS — Lexington, Kentucky, United States
• Bmc Actg Crs — Boston, Massachusetts, United States
• Beth Israel Deaconess - East Campus A0102 CRS — Boston, Massachusetts, United States
• Washington U CRS — St Louis, Missouri, United States
• Univ. of Nebraska Med. Ctr., Durham Outpatient Ctr. — Omaha, Nebraska, United States
• SUNY - Buffalo, Erie County Medical Ctr. — Buffalo, New York, United States
• Beth Israel Med. Ctr. (Mt. Sinai) — New York, New York, United States
• Mt. Sinai Med. Ctr. (N.Y.) A1801 CRS — New York, New York, United States
• Mt. Sinai Med. Ctr. A0404 CRS — New York, New York, United States
• Univ. of Rochester ACTG CRS — Rochester, New York, United States
• Hosp. of the Univ. of Pennsylvania CRS — Philadelphia, Pennsylvania, United States
• University of Washington AIDS CRS — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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