Naltrexone Treatment of Alcohol Dependence
Completed · Phase 4
Conditions studied: Alcoholism
In brief
The long-range goal of this ongoing research program is to find more effective treatments for alcohol dependence by combining medication with the appropriate psychosocial support. This proposal has three specific aims: (1) to compare the effectiveness of naltrexone (Revia) in three types of treatment settings; (2) to assess the effects of psychosocial support on medication compliance and treatment retention; and (3) to investigate the individual characteristics that may predict who is likely to benefit from additional psychosocial support versus simple medication management.
Key facts
- Study ID
- NCT00000452
- Run by
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- People needed
- 240
- Expected to finish
- 2003-01-01
- Last updated by the study team
- 2005-06-24
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Meets criteria for current diagnosis of alcohol dependence.
- Subjects used more than 15 standard alcohol drinks (average)/week with at least 1 day of 5 or more drinks in the past 30 days.
- Successful completion of medical detoxification.
- Lives within a commutable distance to the Treatment Research Center and agrees to follow-up visits.
- Understands and signs the informed consent.
You may not qualify if…
- Current diagnosis of any substance dependence other than alcohol, nicotine, or marijuana.
- Evidence of opiate use in the past 30 days.
- Current treatment with psychotropic medications, including disulfiram (Antabuse) (excluding short-term use of benzodiazepines for detoxification).
- History of unstable or serious medical illness, including need for opioid analgesics.
- Severe physical or medical illnesses such as AIDS, active hepatitis, significant hepatocellular injury as evidenced by elevated bilirubin levels, and current severe psychiatric symptoms.
- Use of an investigation medication in the past 30 days.
- Female subjects who are pregnant, nursing, or not using reliable method of contraception.
Where it is running
- Treatment Research Center, University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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