Behavior and Naltrexone Treatment for Alcoholics

Completed · Phase 4

Conditions studied: Alcoholism

In brief

The study's purpose is to improve alcoholism treatment by investigating the combined effectiveness of a psychotherapy (Coping Skills Training and Cue Exposure Treatment - CSTCET) with naltrexone in a randomized clinical trial. Individuals will receive 2 weeks of CSTCET or a control treatment as inpatients followed by 12 consecutive weeks of receiving either naltrexone or placebo as outpatients. Followups at 24, 48, and 72 weeks after treatment is completed.

Key facts

Study ID

NCT00000449

Run by

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

People needed

160

Expected to finish

2000-03-01

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets criteria for alcohol dependence.

You may not qualify if…

• Current diagnosis of dependence on other substances except nicotine.
• A history of psychosis or current psychotic symptoms.
• Current suicidality, homocidality, or psychiatric symptoms that require additional medication.
• Current use of disulfiram (Antabuse).
• Evidence of significant cerebral, renal, thyroid, or cardiac disease.
• History of opioid abuse in the previous year.
• History of cirrhosis, hepatocellular disease, or elevated bilirubin.
• Females who are pregnant, nursing, or not using a reliable method of birth control.

Where it is running

• Brown University, Center for Alcohol and Addiction Studies — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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