Toward Better Outcomes in Osteoarthritis

Completed · Phase 3

Conditions studied: Osteoarthritis

In brief

This study will determine if there is a difference between commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen (a pain-reliever that does not prevent inflammation) for treating knee pain in osteoarthritis (OA). The two main results we will look at are disease progression according to x-rays and disability over 3.5 years. Study participants with moderate knee OA and knee pain will continue taking their NSAID or stop taking their NSAID and start taking acetaminophen. Every 6 months we will send the participants questionnaires that ask about pain, medication use, and disability. We will take x-rays of the knees at the start of the study and again at the end of the study.

Key facts

Study ID

NCT00000425

Run by

Stanford University

People needed

900

Starts

1996-07-01

Expected to finish

2001-04-01

Last updated by the study team

2013-05-03

Who can join

Age: 50 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Knee osteoarthritis
• Moderate radiographic evidence by Kellgren and Lawrence grade 2-4
• Knee pain > 20 on VAS pain scale

You may not qualify if…

• Bilateral knee replacements
• Unwillingness to take acetaminophen for pain relief

Where it is running

• San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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