Tidal Lavage in Knee Osteoarthritis
Completed · Phase 2 · Has a placebo group
Conditions studied: Osteoarthritis, Knee
In brief
This study compared the effects of tidal lavage (washing out) of the knee joint and an imitation lavage procedure in people with knee osteoarthritis. In tidal lavage, the doctor flushes out a knee joint with repeated injections of a mild salt solution, done under local anesthesia. Study participants had to meet standard criteria for diagnosis of osteoarthritis but could have low, medium, or high severity of x-ray changes indicating knee osteoarthritis. We performed the lavage procedure once, and did quarterly followups for 1 year. We permitted patients to use some other osteoarthritis treatments during the study, such as non-narcotic pain relievers, nonsteroidal anti-inflammatory drugs, and physical therapy.
Key facts
- Study ID
- NCT00000424
- Run by
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- People needed
- 180
- Starts
- 1995-07-01
- Expected to finish
- 2001-06-01
- Last updated by the study team
- 2007-01-01
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Knee pain attributed to osteoarthritis for at least 1 year.
- Meet American College of Rheumatology clinical or clinical plus x-ray criteria for knee osteoarthritis
- Have at least a moderate pain rating on at least one of the five Western Ontario-McMaster University Osteoarthritis Index (WOMAC) scales
You may not qualify if…
- Significant conditions of the spine, hips, or feet that affect the ability to walk
- Significant medical conditions that affect the ability to walk and function
- Inflammatory arthritis, such as rheumatoid arthritis or gout
- Degenerative arthritis secondary to other conditions, such as hemochromatosis, Wilson's disease, or ochronosis
- Current significant soft tissue rheumatism such as fibromyalgia, anserine bursitis, or trochanteric bursitis
Where it is running
- Indiana University School of Medicine — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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