Effects of Strength Training on Knee Osteoarthritis
Completed · Phase 2
Conditions studied: Osteoarthritis, Knee
In brief
To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 \& 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 \& 3) have the same response to training as those without joint pain.
Key facts
- Study ID
- NCT00000406
- Run by
- Indiana University
- People needed
- 280
- Starts
- 1977-09-01
- Expected to finish
- 2006-11-01
- Last updated by the study team
- 2013-04-30
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and females 60 to 100 years of age
You may not qualify if…
- Knee joint replacement surgery
- Diabetes mellitus
- Uncontrollable hypertension
- Neuropathies of the lower extremity
- Poor mental cognition (i.e., inability to follow instructions)
Where it is running
- National Institute for Fitness and Sport — Indianapolis, Indiana, United States
Full record on ClinicalTrials.gov
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