Antifolate Effectiveness in Arthritis

Completed · Phase 2

Conditions studied: Rheumatoid Arthritis, Adjuvant Arthritis

In brief

This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known as folic acid. We are studying the biochemical reactions affected by this vitamin because we think that blocking many of these reactions may be necessary for methotrexate to work in treating rheumatoid arthritis. Through these studies, we hope to gain a better understanding of how this drug and related drugs work as treatments for arthritis.

Key facts

Study ID

NCT00000395

Run by

University of Alabama at Birmingham

People needed

40

Starts

1996-09-01

Expected to finish

2002-08-01

Last updated by the study team

2016-12-16

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals starting methotrexate for rheumatoid arthritis.
• Study subjects should not currently be taking folic acid-containing vitamins.

You may not qualify if…

• Cancer, renal, or liver disease.
• Previous use of methotrexate within the past 6 months or current use of folic acid-containing supplements.

Where it is running

• The University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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