Effects of Stimulant Dependence on Human Striatal Dopamine System - 15

Status unconfirmed · Phase 1

Conditions studied: Amphetamine-Related Disorders, Tobacco Use Disorder

In brief

The purpose of this study is to determine whether DAT availability, assessed by WIN binding, in the striatum is altered in cocaine or methamphetamine dependence. To determine whether DA synthesis capacity, assessed by FDOPA uptake, in the striatum is altered in Coc or Meth dependence. To determine whether the PET tracers, WIN or FDOPA, will differentiate Meth induced alterations from those induced by Coc use. To determine whether the PET characterization of striatal alterations observed at 3-5 days since last drug use persists at least 3 months after last drug use.

Key facts

Study ID

NCT00000350

Run by

National Institute on Drug Abuse (NIDA)

People needed

0

Starts

1999-03-01

Last updated by the study team

2017-01-11

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• M/F, ages 21-50. Meet DSM-IV criteria for methamphetamine and nicotine dependence. Agree to conditions of the study and sign informed consent.

You may not qualify if…

• Psychiatric disorder that requires medication therapy. History of seizures. Pregnant and/or nursing women. Dependence on ETOH or benzodiazepines or other sedative/hypnotics. Acute hepatitis. Other medical conditions that deem participation to be unsafe.

Where it is running

• Friends Research Institute — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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