Role of Metabolites in Nicotine Dependence (2) - 5
Completed · Phase 2
Conditions studied: Tobacco Use Disorder
In brief
The purpose of this study is to determine the effects of varying doses of cotinine on cigarette self-administration.
Key facts
- Study ID
- NCT00000288
- Run by
- National Institute on Drug Abuse (NIDA)
- People needed
- 0
- Starts
- 1995-12-01
- Expected to finish
- 2002-12-01
- Last updated by the study team
- 2017-01-12
Who can join
Age: 21 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male/Female subjects ages 21-45 yrs. inclusive, with a smoking history of at least 1 pack of cigarettes daily for at least 1 year. Subject must be in good health as verified by medical history, screening examination, and screening laboratory tests. Subject must provide written informed consent to participate in the study and be motivated to stop smoking for a short term.
You may not qualify if…
- History of myocardial infarction, angina pectoris, sustained or episodic cardiac arrhythmias, symptomatic peripheral vascular disease, peptic ulcer disease or any other medical condition which the physician or investigator deems inappropriate for participation. Insulin-dependent diabetes. Pregnant or lactating, or not using adequate birth control methods. Requirement of any form of regular psychotropic medication (antidepressants, antipsychotics, or anxiolytics) and recent psychiatric history). Chronic use of systemic steroids or antihistamines. Skin sensitivity which would preclude use of a transdermal system. Abuse of alcohol or any other recreational or prescription drug. Use of any other tobacco products including smokeless tobacco and nicotine products. Previous use of transdermal nicotine system. Inability to fulfill all scheduled visits and examination procedures throughout the study period.
Where it is running
- University of Minnesota — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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