Effects of Phenytoin on Cocaine Use in Humans - 2

Completed · Phase 1

Conditions studied: Cocaine-Related Disorders

In brief

The purpose of this study is to determine the effects of phenytoin on the self-administration of smoked cocaine.

Key facts

Study ID

NCT00000285

Run by

National Institute on Drug Abuse (NIDA)

People needed

0

Starts

1996-05-01

Expected to finish

2001-12-01

Last updated by the study team

2017-01-12

Who can join

Age: 20 and older, up to 45. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males/Females between the ages of 20-40. History of smoked cocaine use on the avg. of at least 2 times/week over a 6 month period. Have currently used at least 1 g of cocaine within a 4-6 hr period. Current history of good health, normal serum albumin levels and normal QTc intervals. Nonreactive for HIV. No participation in any of our studies for the past 6 months. For females: not pregnant as determined by pregnancy screening nor breat feeding, and using acceptable birth control methods (e.g. birth control pills, diaphragm, condoms plus foam).

You may not qualify if…

• History of suicide attempt, bipolar disorder, schizophrenia, or generalized anxiety disorder. Current problem with major depressive disorder. Current use of alcohol or other durgs on a daily basis. History of major medical illnesses. Currently on parole, probation or a legal history of violence. Treated for chemical dependency within the past 6 months. Use of any psychotropic drugs including MAOIs in the past 6 months.

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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