Agitation in Alzheimer's Disease

Completed · Phase 3

Conditions studied: Alzheimer Disease

In brief

Agitation affects 70 to 90 percent of patients with AD. Signs of agitation include verbal and physical aggressiveness, irritability, wandering, and restlessness. These behaviors often make caring for patients at home very difficult. Trazodone and haldol are two of the most commonly prescribed drugs for agitation in AD patients. Behavior management, a non drug approach, has been effective in reducing signs of agitation. Researchers have yet to compare the effectiveness of drug versus non drug therapy to treat agitation in AD patients and determine which is the best treatment. The Alzheimer's Disease Cooperative Study, with funding from the National Institute on Aging, is conducting an agitation treatment program at 21 sites in 16 States. This study will assess which of the above treatments is most effective.

Key facts

Study ID

NCT00000179

Run by

National Institute on Aging (NIA)

Last updated by the study team

2005-06-24

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Memory problem consistent with a probable diagnosis of Alzheimer's disease (AD)
• Agitation symptoms for at least the past 2 weeks
• Patient has caregiver who can participate
• Patient lives in the same household as the caregiver

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States
• University of California, San Diego — San Diego, California, United States
• University of Miami — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Southern Illinois University — Springfield, Illinois, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kentucky — Lexington, Kentucky, United States
• University of Massachusetts — Worcester, Massachusetts, United States
• University of Michigan — Ann Arbor, Michigan, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• New York University Medical Center — New York, New York, United States
• Mount Sinai Medical Center — New York, New York, United States
• University of Rochester — Rochester, New York, United States
• University Hospitals of Cleveland — Cleveland, Ohio, United States
• Oregon Health Sciences University — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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