Estrogen Hormone Protocol

Completed · Phase 3

Conditions studied: Alzheimer Disease

In brief

Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.

Key facts

Study ID

NCT00000177

Run by

National Institute on Aging (NIA)

People needed

120

Starts

1995-10-01

Expected to finish

1999-01-01

Last updated by the study team

2009-12-11

Who can join

Age: 60 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.

You may not qualify if…

• Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.

Where it is running

• University of Alabama, Birmingham — Birmingham, Alabama, United States
• University of California, San Diego — San Diego, California, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Rush Presbyterian St. Luke's Medical Center — Chicago, Illinois, United States
• Southern Illinois University — Springfield, Illinois, United States
• Indiana University Medical Center — Indianapolis, Indiana, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Kentucky — Lexington, Kentucky, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Mayo Clinic — Rochester, Minnesota, United States
• Washington University — St Louis, Missouri, United States
• New York University Medical Center — New York, New York, United States
• Mount Sinai School of Medicine — New York, New York, United States
• Columbia Presbyterian Medical Center — New York, New York, United States
• Burke Medical Research Institute — White Plains, New York, United States
• University Hospitals of Cleveland — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Texas — Dallas, Texas, United States
• Baylor College of Medicine — Houston, Texas, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.