Longitudinal Study of Ocular Complications of AIDS (LSOCA)

Completed

Conditions studied: HIV Infections, Acquired Immunodeficiency Syndrome, Cytomegalovirus Retinitis

In brief

To monitor trends over time, in the incidence of CMV retinitis and other ocular complications of AIDS To determine the effect of highly active anti-retroviral therapy (HAART)-induced immune status on the risk of developing CMV retinitis and other ocular complications of AIDS To determine the characteristics (clinical, virologic, hematologic, and biochemical) of a population at high risk for CMV retinitis and other ocular complications of AIDS To evaluate the effects of treatments for CMV retinitis and other ocular complications on visual function, quality of life, and survival.

Key facts

Study ID

NCT00000168

Run by

Johns Hopkins Bloomberg School of Public Health

People needed

2392

Starts

1998-08-01

Expected to finish

2013-08-01

Last updated by the study team

2015-06-12

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of AIDS according to the 1993 Centers for Disease Control and Prevention (CDC) definition (with or without clinical symptoms of CMV retinitis or other ocular complications of AIDS)
• Age 13 years or older
• Signed consent statement
• Patients with newly diagnosed (within 45 days of enrollment) Ocular Opportunistic Infections (OOIs)
• Patients without a newly diagnosed Ocular Opportunistic Infection (OOI) diagnosed with AIDS after 1 Jan 2001

You may not qualify if…

• none.

Where it is running

• University of California, Irvine — Irvine, California, United States
• Shiley Eye Center, 0946 — La Jolla, California, United States
• University of Southern California — Los Angeles, California, United States
• Jules Stein Eye Institute — Los Angeles, California, United States
• Francis I. Proctor Foundation — San Francisco, California, United States
• Bascom Palmer Eye Institute — Miami, Florida, United States
• University of South Florida — Tampa, Florida, United States
• Emory Eye Clinic — Atlanta, Georgia, United States
• Northwestern University — Chicago, Illinois, United States
• Division of Infectious Diseases, University of Indiana, Indianapolis — Indianapolis, Indiana, United States
• LSU Eye Center — New Orleans, Louisiana, United States
• The Wilmer Ophthalmological Institute, The Johns Hopkins University School of Medicine — Baltimore, Maryland, United States
• UMDNJ-New Jersey Medical School — Newark, New Jersey, United States
• Department of Ophthalmology — New York, New York, United States
• Department of Ophthalmology — New York, New York, United States
• University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Texas Medical Branch — Galveston, Texas, United States
• Cullen Eye Institute — Houston, Texas, United States

Full record on ClinicalTrials.gov

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