Herpetic Eye Disease Study (HEDS) II

Completed · Phase 3

Conditions studied: Keratitis, Herpetic, Ocular Herpes Simplex, Herpes Simplex

In brief

To determine whether early treatment (with oral acyclovir) of herpes simplex virus (HSV) ulcerations of the corneal epithelium prevents progression to the blinding complications of stromal keratitis and iridocyclitis. To determine the efficacy of low-dose oral acyclovir in preventing recurrent HSV eye infection in patients with previous episodes of herpetic eye disease. To determine the role of external factors (such as ultraviolet light or corneal trauma) and behavioral factors (such as life stress) on the induction of ocular recurrences of HSV eye infections and disease.

Key facts

Study ID

NCT00000139

Run by

National Eye Institute (NEI)

Starts

1992-10-01

Last updated by the study team

2010-03-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Francis I. Proctor Foundation, University of California, San Francisco — San Francisco, California, United States
• Emory Eye Center — Atlanta, Georgia, United States
• Eye Center, University of Illinois, Chicago — Chicago, Illinois, United States
• Louisiana State University Eye Center — New Orleans, Louisiana, United States
• Department of Ophthalmology, The Mount Sinai Medical Center — New York, New York, United States
• Wills Eye Hospital, Cornea Clinic — Philadelphia, Pennsylvania, United States
• Cullen Eye Institute, Baylor College of Medicine — Houston, Texas, United States
• The Eye Institute, Medical College of Wisconsin — Milwaukee, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.